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Insufficient intake The most common cause of vitamin B12 deficiency is insufficient intake (absorption), which can be caused by the following: excessive bacterial growth in the small intestine impaired absorption (malabsorption) due to coeliac disease [1] or a disease of the pancreas inflammatory diseases of the small intestine (vitamin B12 is absorbed in the small intestine) surgery on the gastrointestinal tract

Timing and dosing should be guided by clinical context

Instead, its activity is believed to be mediated via adipocyte-specific signaling cascades, which gives the fragment a uniquely narrow pharmacological footprint for a peptide of its molecular size and makes it attractive to investigators who want clean lipolytic readouts