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Detoxification of NAPQI occurs through its binding to the sulfhydryl group of glutathione (GSH) to form APAP-GSH, which is ultimately excreted in the urine as cysteine and mercapturic acid conjugates (APAP-cys) [5,9]

This highlights the sensitivity of the CNS to diseases with such profound protein dyshomeostasis
A weak immune system fails to protect your body from harmful substances and aggressive germs and can cause frequent infections, high levels of stress, fatigue, etc

Additionally, by blocking Toll-like receptor 4, naltrexone may also alleviate neuroinflammation in ME/CFS [149]