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In a 12 months RCT, obese patients receiving 2000 IU vitamin D daily and lifestyle-based weight loss programme did not have significant reduction in body weight, body composition, BMI, insulin and C-reactive protein (CRP) levels when compared with the placebo group who received lifestyle-based weight loss programme only (Reference Mason, Xiao and Imayama50)

10.1016/s0140-6736(11)61452-9 44 RaymanM

doi: 10.1097/00000478-199405000-00007

Given the likely difference in mechanism, it is possible that pyruvate depleting conditions may be used in combination with other dispersion-inducing conditions to further augment the efficacy of the dispersion response