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Two enzymes are involved in glutathione synthesis

The five most upregulated genes in microglia/macrophages were HSPH1, HSPB1, HSP90AA1, CHORDC1 and PTGES3, while the five most downregulated genes were CD14, SLC2A3, CCDC26, HAMP and TMEM163 (Fig

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20%), but the difference between the two treatment groups was not statistically significant [172], possibly because the study was clearly underpowered (1200 patients would have been required to achieve statistical significance with respect to this endpoint)