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To overcome this issue, Cudalbu and colleagues [111] reported biological features of invasive tumour growth based on transcriptomic and metabolic changes observed in mouse xenografts and in the corresponding patients tumours

Interestingly, despite the presence of oxygen, quiescent ECs predominantly rely on glycolysis to generate approximately 85% of their ATP and bypass OXPHOS, likely due to their low mitochondrial content [25,26,27,28,29]

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Glutathione helps keep these energy factories running smoothly by minimizing oxidative stress