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In earlier trials, about 70% of patients experienced at least one mild adverse effect similar to those seen with other vaccines, including injection site pain, rash, headaches, muscle soreness, and fevers

Digby, G
This was achieved by initially synthesizing the 128 AAs sequence bearing Phe67 to a Glu mutation via flow synthesis and the subsequent on-bead lactam formation between Lys58/60 and Glu67 (Fig
