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C1P and C2 ceramides also regulate the dynamics of the cytoskeleton and axonal guidance by their effects on G-protein coupled receptors coupled to Rho GTPases signaling

Large amounts of ROS generation due to the downregulated mitochondrial superoxide dismutase 2 (SOD2) also impairs tumor-infiltrated T cells, and scavengers that neutralize mitochondrial ROS can partially restore CD8 + T cells function [28]

doi: 10.3181/00379727-97-23764