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In advanced COPD, peripheral airways obstruction, parenchymal destruction, and pulmonary vascular abnormalities reduce the lungs capacity for gas exchange, producing hypoxemia and, later on, hypercapnia
Elevated homocysteine levels can lead to the build-up of a molecule called S-Adenosyl Homocysteine (SAH)
These enzymes were, therefore, not used for further screening experiments with the novel synthesised compounds
