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Initiate treatment with the EPKINLY step-up dosage schedule to reduce the incidence and severity of CRS

In the context of periodontitis, the increased expression of SLC7A11 likely represents a compensatory response to elevated oxidative stress, as ferroptosis characterized by iron-dependent lipid peroxidation has been shown to be involved in inflammatory diseases including periodontitis [24]

J Inorg Biochem 2000;82: 2732

As discussed below, such domains will spontaneously aggregate together with similar or different proteins, increasingly destabilizing the function of such oxidatively modified proteins and eventually leading to cell death