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The other phase IIa study also confirmed improved glycemic control in those with obesity and T2DM, but also reported decreased body weight and improvement of blood lipids compared to placebo [44]

Phase Maintenance Weeks 25+ Tirzepatide 15.0 mg/week Cagrilintide 2.4 mg/week Notes Full 3-receptor coverage if tolerated

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TABLE 6 Precision of diosgenin, charantin, and hydroxychalcone in rat plasma