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Among these age-related modifications, the impairment in HPA axis feedback inhibition with age, which is followed by increased plasma cortisol levels, holds a prevalent role and may explain the increased stress susceptibility in geriatric patients (165)
Most gut peptide research has been conducted in rodent models, and while the mechanistic data is compelling, translation to human outcomes has not been established through large clinical trials
doi: 10.1080/07315724.2004.10719409 98
Crane, M
