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Indeed, TJs allow the paracellular transport of some medium-sized hydrophilic molecules, ions, or positively charged molecules but prevent the transport of proteins, such as antigenic macromolecules, lipids, and microbial-derived peptides (168)

When it decides to go on a holiday (read: when levels drop), it leaves us open to a host of issueseverything from serious heavy-hitters like cancer and heart trouble, to diabetes and age-related concerns (NCBI)

Acta 964 377382 10.1016/0304-4165(88)90038-4 [DOI] [PubMed] [Google Scholar] Orrenius S., Gogvadze V., Zhivotovsky B

published in-vitro findings on hTERT upregulation in human somatic fibroblast cell cultures