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Not strictly required, but useful

The release of Nrf2 from Keap1 is also achieved by its phosphorylation on Ser40 by several kinases such as protein kinase C (PKC), casein kinase-2 (CK2), phosphoinositide-3-kinase (PI3K), c-Jun NH 2 -terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and protein kinase RNA-like ER kinase (PERK) (82)

Pro-inflammatory mediators Pro-inflammatory Mediators Obesity-induced inflammation in AT involves macrophage infiltration and stress pathway activation, with NF-B driving production of cytokines (TNF-, IL-6, IL-1) that disrupt insulin signaling (67, 68)

Megaloblastic anemia, which is characterized by an abundance of abnormally large and dysfunctional red blood cells, is most commonly caused by folate and/or B12 deficiency