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ROS-promoting pro-tumorigenic signaling It has been demonstrated that mammalian cells express three Ras proteins, H-Ras, K-Ras, and N-Ras that promote tumorigenesis following mutational activation (Pylayeva-Gupta et al
Enzymatic Functions of Aldehyde Dehydrogenase Isozymes During embryogenesis, many developmental genes are transcriptionally regulated by retinoic acid (RA), the active metabolite of vitamin A and RA receptors (Niederreither and Doll, 2008)
