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It is estimated to occur in 1 in 750,000 to 2,000,000 infants in the United States
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This paper demonstrates that phorbol 12-myristate 13-acetate induces transformation-related phenotypes in a cell line overexpressing-Src, and provides strong evidence that the tumour-promoter activity of phorbol esters might be due to downregulation of a growth inhibitory PKC (PKC)
