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They promote tumour angiogenesis mainly by secreting pro-angiogenic growth factors and facilitating the degradation of the perivascular extracellular matrix

T.et al.2009Long-term outcomes among adult survivors of childhood central nervous system malignancies in the Childhood Cancer Survivor Study, 6

The added glucagon-receptor agonism is the differentiator it raises basal energy expenditure and shifts the substrate-utilisation profile toward fat oxidation, which is the hypothesised explanation for the larger weight-loss magnitudes reported in Phase 2

A large proportion come from China, where imports of hormone and peptide compounds have increased dramatically: US customs data shows they hit $328m in the first three-quarters of 2025, up from $164m in the same period the previous year, the New York Times reported