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Our main motivation to generate a C/EBP-based system came from our recent studies where we showed that experimental prevention of uORF-dependent translation re-initiation and the resulting decrease in LIP expression (decrease in LIP/LAP ratio) leads to CR-like metabolic improvements 12,17,29

WLL in this case was safe and improved the respiratory clinical situation
Acetylcholine is a fundamental neurotransmitter that enables the communication between neurons

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