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Additionally, after IOPs treatment, the protein expression of PI3K-p85, p-Akt (ser473), and glucose transporter protein 4 (GLUT4) was upregulated, suggesting that the anti-hyperglycemic mechanism of IOPs may involve the activation of PI3K and Akt phosphorylation, and GLUT4 transport in diabetic mice (Wang et al., 2017)

BMJ Open 8 , e022404 (2018)

Statler et al, 2023)

10. Are there any contraindications
