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A comparison of the gene expression profiles of peripheral blood mononuclear cells (PBMCs) in elderly men and women with younger controls revealed that 48 signaling pathways are altered in females, compared to only 29 in males

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[67] Cardiovascular disease [edit] Increased IGF1 levels are associated with a 16% lower risk of cardiovascular disease and a 28% reduction of cardiovascular events

This RNA regulates cell proliferation, invasion, and migration by interacting with miR-181a-5p and controlling the expression of SIRT1