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MOTS-c regulates cell metabolism primarily through the AICAR (5-aminoimidazole-4-carboxamide ribonucleotide)-AMPK pathway, which controls glycolysis, mitochondrial activity, and fatty acid oxidation [12]

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In oxaliplatin-treated mice, aluminum was accumulated in the dorsal root ganglia (DRG), and accumulated aluminum in DRG or other organs aggravated oxaliplatin-induced neuropathic pain