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The transcription factor Nrf2, possibly in complexes with other Jun or Maf proteins, was found to be responsible for trans -activating the human GCLC promoter via binding to ARE4 in response to numerous treatments including -NF, pyrrolidine dithiocarbamate, TBH [104,105], and insulin [106]

Food & Drug Administration website, accessed 08/24/2022 from: 4 Civil Money Penalties Relating to the ClinicalTrials.gov Data Bank Guidance for Responsible Parties, Submitters of Certain Applications and Submissions to FDA, and FDA Staff, August 2020, from the U.S