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ascorbate-glutathione cycle The ascorbate–glutathione coming of age ascorbate glutathione cycle Structural understanding
Description
In the last decades, our knowledge of the molecular mechanisms behind the biological action of (poly)phenols has substantially grown
Although ARE/EpRE, AP-1 and NFB may be responsible for basal expression and induction of GCLC by many of the pro- and anti-oxidants, recently c-Myc has been identified to also contribute to the basal expression and induction of human GCL under oxidative stress (Benassi et al., 2006)
doi:10.1002/phar.1302 Levy DS, Grewal R, Le TH
(September 2015)
