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TM represents a promising multifaceted approach to cancer therapy, involving mechanisms such as angiogenesis inhibition, interference with copper-dependent enzyme functions, apoptosis induction, immune modulation, and overcoming chemotherapy resistance

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However, the in vitro data indicate that this cytotoxicity and the perforin expression levels in NK cells appear to be dependent upon endogenous IGF-1 and miR-483-3p expression, given that they can be inhibited by either IGF-1-neutralizing antibody or miR-483-3p overexpression

Here we ask whether killifish undergo age-dependent changes in the main hematopoietic organ (kidney marrow), which may contribute to systemic aging