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First, it means the quality may decline once this date has passed
"The red wine extract-induced activation of endothelial nitric oxide synthase is mediated by a great variety of polyphenolic compounds." Mol Nutr Food Res 54 Suppl 2 : S171-183
In rats, TMAO increases with age and causes oxidative stress and inflammation in blood vessels, leading to endothelial (blood vessel lining) dysfunction, which increases the risk of heart disease [12]
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