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E.BrandiR.DonofrioM.et al
While IGF-1 LR3 was engineered for extended half-life and systemic activity, IGF-1 DES follows the opposite strategy: very short half-life (20-30 minutes) but extreme potency at the site of injection
Reactive cysteines in proteins from two distinct proteomes are firstly alkylated with IA-alkyne probe, subsequently conjugated with isotopically differentiated cleavable biotin-azide tag using CuAAC (Figure 6A)
Hepatology 2006;43(6):122030
