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Experimental studies on cultured ECs have shown that Hcy can induce inflammation by inducing a variety of inflammatory cytokines, such as interleukin (IL)-1 (67), IL-6 (68), IL-8 (69, 70), IL-18 (71), and tumor necrosis factor (TNF)- (72), which may be due to the ROS accumulation, inflammasome activation, nuclear factor kappa-B (NF-B) activation

Figure 4: Effects of Intrinsic Factors on Aripiprazole Pharmacokinetics Figure 5: Effects of Intrinsic Factors on Dehydro-aripiprazole Pharmacokinetics Carcinogenesis Lifetime carcinogenicity studies have not been conducted with aripiprazole lauroxil