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It is important to state that in the midst of this topsy-turvy situation, where the world is desperately seeking for effective COVID-19 antidote, recently a warning regarding a probable adverse effect of ibuprofen in aggravating the current coronavirus infection has also come up [80]

Superoxide radical and hydroperoxyl radical An important electron transfer reaction occurs in mitochondria via leakage of an electron from the electron transfer chain to oxygen during oxidative phosphorylation, resulting in the formation of a primary radical, superoxide radical anion (O 2 + e O 2 ) (Boveris and Cadenas 1982)

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In their experiments, all coumarin derivatives showed antioxidant activity in the DPPH assay, while daphnetin and fraxetin also showed antioxidant activity by inhibiting lipid peroxidation