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The activation of sirtuins, proteins strongly associated with longevity, provides additional anti-aging benefits

Baseline and interval laboratory monitoring should include: fasting glucose and HbA1c (tirzepatide can cause hypoglycemia in non-diabetic subjects if caloric intake drops too low), lipase and amylase (pancreatitis risk with GLP-1 agonists), liver function tests (AST, ALT, bilirubin), and thyroid panel (TSH, free T3, free T4)

+ Frequency depends on your deficiency level

Each receptor system contributes distinct metabolic effects and GLP-1 influencing insulin secretion and appetite, GIP influencing incretin response and fat cell biology, and glucagon driving energy expenditure and hepatic fat metabolism