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By contrast, it was demonstrated that SFN (5 M) pretreatment or vitamin E before to induce the model blocked the ASK1 signaling pathway and prevented both oxidative stress and cell death

Malays J Med Sci 26:28 de Water E et al (2018) Prenatal manganese exposure and intrinsic functional connectivity of emotional brain areas in children

This limitation necessitates higher doses to achieve clinical efficacy, which may result in systemic side effects

The ENS, comprising the myenteric and submucosal plexuses, facilitates local neural communication within the intestinal tract and integrates with the autonomic nervous system (Dowling et al., 2022