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Conversely, a chronic increase of ROS can either overwhelm the responsive capacity of these pathways or induce the oxidation of specific components of UPR, UPS, or autophagy, thus exacerbating the accumulation of unfolded/misfolded proteins (333, 334) (FIGURE 9)

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[DOI] [PubMed] [Google Scholar] 66.Sendagorta E, Feito M, Ramrez P, Gonzalez-Beato M, Saida T, Pizarro A

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