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Goulas, A., Betzel, R
AA147 covalently modifies KEAP1 to promote NRF2 activation in HT22 cells NRF2 activity is primarily regulated through its interaction with the redox sensor E3 ligase protein KEAP1 ( Fig
PD-MCI in the posterior cingulate cortex exhibited reduced N-acetyl aspartate (NAA), total NAA, choline, glutathione, glutamate + glutamine, and total creatine (tCr) levels but both elevated myo-inositol (Ins) and Ins/tCr ratio, but reduced NAA/Ins ratio
Accordingly, loss of SIRT4 enhances glutamine-dependent proliferation and genomic instability, which simultaneously contribute to tumorigenesis 151
