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It should be noted, however, that the methylene-tetrahydro-folate-reductase (MTHFR) enzyme reduces 5,10-methylene THF to 5-methyl THF and only functions when vitamin B12 is present as a cofactor (Fig
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For the TG clearance tests, mice were fasted overnight (~15 h), then administered 20% intralipid (Sigma-Aldrich) via oral gavage (15 l g 1 body weight) at ZT2
