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Description
Another neurodegeneration condition is ataxia-telangiectasia (A-T), a disorder caused by mutations in the ataxia-telangiectasia-mutated (ATM) kinase gene
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Proteostasis regulators have emerged as alternative approaches to circumvent CFTR defect by improving defective proteostasis thus avoiding unwanted protein-protein interactions and reinstating desirable interactions for misfolded CFTR variants
If the wrong amino acid gets loaded, the entire protein could misfold
