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LA also shares structural similarities to the Vibrio cholerae zonula occludens toxin (Zot), which is an enterotoxin that disrupts intercellular tight junction structure through actin polymerization and cytoskeletal modifications that result in increased intestinal permeability through intracellular signaling (8)

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Kong and Wada, 2016)

Route of Elimination In man, following a single dose of 4 mg/m2 of pentostatin infused over 5 minutes, approximately 90% of the dose was excreted in the urine as unchanged pentostatin and/or metabolites as measured by adenosine deaminase inhibitory activity