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Mechanistically, the CD73/A2AR signaling cascade coordinates the de novo synthesis and consumption of GSH with GSSG accumulation and concomitant mitochondrial lipid peroxidation, which links potentially to PKA/E2F1dependent fine-tuning of the ratio of GSR to GPX4

This is due to the very wide definition of moderate toxicity in PPDB
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Dual effect of ceramide on human endothelial cells: Induction of oxidative stress and transcriptional upregulation of endothelial nitric oxide synthase
Frequently Asked Questions What are the main n-acetyl cysteine uses
