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Moreover, with melatonin specifically, the physiological kinetics and circadian rhythm need consideration, ideally taking a physiological dose (0.30.5 mg) of melatonin with sustained release properties and going into darkness a minimum 30 min before desired sleep, thereby mimicking the physiological kinetics based on light and dark patterns as well as the typical endogenous trajectory of immediate and then sustained release over four to five hours (See Figure 9)
In the laboratory, EPI-743 a broader, more potent derivative of the antioxidant CoQ10 successfully rescued human muscle cells under oxidative stress and returned them to a normal state
