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Similar results were obtained in rat plasma samples, showing recovery rates of 104.01% 0.41%, 89.38% 3.79%, and 101.42% 1.31% for the same concentrations of 3, 48, and 150 ng/mL, respectively, with corresponding NMF of 1.15% 9.39%, 0.84% 4.27%, and 1.01% 0.41%
Subsequently, delivery of CuET and co-delivery of DSF/Cu became prominent
Major strengths of the study include the randomized controlled design with blinding of study personnel and the rigor of the study methods where milk was provided to participants weekly with milk measuring containers, daily self-adherence tracking by participants, and rigorous weekly monitoring of study adherence of participants by study staff
However, cold shock (22C) caused severe growth arrest in gpp2 strains relative to wild type and reconstituted strains in YEPD (Figure 1A)
