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The results revealed that JM1 cells induced by HBV + HCC cells significantly reduced IFN- expression levels in Jurkat cells upon co-culture

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Although the C-terminal SAM-binding site is located away from the catalytic center, it was revealed that SAM binding induces a structural rearrangement of the catalytic core that relieves autoinhibition and stabilizes an activated conformation (Prudova et al., 2006)

It is known that JNK activation is mediated by oxidative stress and plays pathogenic roles in a diverse array of cellular programmes, including cell differentiation, movement, proliferation and death 34