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Gene set enrichment analysis of the PC1 loadings showed E2F and MYC targets and mTORC1 pathway genes in the top ten under both normoxic and hypoxic conditions, with hypoxia and glycolysis genes under normoxic conditions and oxidative phosphorylation, and epithelial mesenchymal transition genes under hypoxic conditions (Supplementary Table 4)

Helps improve skin texture & smoothness

47,48 Dysregulated inflammatory signaling by fat tissue and release of growth factors, cytokines, and free radicals from the ovaries, liver, and other tissues contribute to the inflammatory state and promote further metabolic imbalance and insulin resistance

While this patient likely has concurrent protein malabsorption, his prominent steatorrhea indicates that fat malabsorption is the primary driver of his symptoms, making lipase the more critical intervention