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Barrier Disruption by Specific Microbes Intestinal pathobionts are often overrepresented in the microbiota of patients with inflammatory disorders, where they accelerate systemic inflammation by translocating across the epithelial barrier to reach extraintestinal tissue ( Figure 1 )

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This work now shows a direct line from biochemical and biophysical understanding of protein interactions to an inhibitor, says Kritzer, who was not involved in the research

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