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Consequently, the lesions induced in rats share a considerably high degree of similarity with corresponding lesions in human patients

Recent reports have shown that the shear-induced opening of endothelial Piezo1 channels activates the calcium-dependent protease calpain (Li et al., 2014), which in turn cleaves talin (a protein that links membrane integrins to the actin cytoskeleton) to alter integrin-mediated cell adhesion (McHugh et al., 2010)

On the antioxidant front, GHK-Cu increases superoxide dismutase (SOD) activity through copper cofactor delivery, elevates catalase activity for hydrogen peroxide breakdown, and increases total glutathione levels