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RNA sequencing and pathway enrichment analysis show FOXO4-DRI significantly downregulates extracellular matrix-receptor interaction pathways, including fibronectin (Fn1), tenascin C (Tnc), and thrombospondin 2 (Thbs2), all critical components of fibrotic tissue architecture

International immunopharmacology, 2013, 15(2): 240- 245

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In light of the lackluster clinical results, the companys shares plunged to the lowest its been since the 1980s
