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It is sourced both from the diet and synthesized within the body from the essential AA methionine through the transmethylation and transsulfuration pathways (Cunningham et al

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Analusis 26 , 347351 (1998)

These findings suggest that defects in the remethylation and transsulfuration pathways may contribute to the elevated homocysteine levels observed in children with autism spectrum disorder.35 Epidemiological studies have found that individuals experiencing major depressive disorder and bipolar disorder have elevated plasma levels of homocysteine and deficient plasma levels of folate and vitamin B12.35 The effect of reducing plasma homocysteine levels on the symptomology of these neurological disorders has not been well-studied, and clinical trials investigating associations between folic acid and vitamin B12 supplementation and mood disorders have provided inconsistent results