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Description
The activated Nrf2-sMaf heterodimer binds to antioxidant response element (ARE) sequences in the promoter of a tandem of antioxidant genes, including heme oxygenase-1 (HMOX1), aldo-keto reductases, glutathione, and glutathione-S-transferase (Tonelli et al., 2018), to trigger their expression
Barker, G
found that circLMO7 activated the WNT2/-catenin signaling pathway by releasing miR-30a-3p, which inhibits its target gene WNT2 (64)
This disrupts the interaction between LDHB and LONP1, leading to the accelerated degradation of TFAM ( Figure 3 )
