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This approach may be particularly effective in tumors with concurrent LKB1 and KEAP1 mutations that exhibit enhanced SHMT-dependent metabolism

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doi:10.1016/j.cell.2012.12.029 pmid:23374344 Zhang Y, Kuang Y, Xu K, Harris D, Lee Z, LaManna J, Puchowicz MA (2013) Ketosis proportionately spares glucose utilization in brain

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