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12 Furthermore, exposure to genotoxic agents such as chemotherapy drugs (eg, busulfan and mitomycin C), environmental toxicants, oxidative stress, and radiation can also contribute to PHG by damaging melanocytes or disrupting melanogenic signaling

Some research suggests potential benefits of arginine supplementation in pregnancy-related complications such as pre-eclampsia (high blood pressure in pregnancy), for example, arginine infusions have been associated with lowered blood pressure and improved outcomes in women with pre-eclampsia
