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Complementarily, IGF-1R preferentially activates IRS-2 [120] as it was found that IRS-2 contains a KLRB domain that functions to block the tyrosine kinase domain in the cytoplasmic region of the IR, and that such does not happen in the IGF-1R

Pissios P., Nicotinamide N-methyltransferase: more than a vitamin B3 clearance enzyme, Trends Endocrinol Metab, 2017

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Bone, joint, and neuromuscular systems: Benefits in bone repair, spinal cord and peripheral nerve injury, and neuromuscular junction stabilization, including antispasticity and improved functional recovery in some animal models