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Description
Antioxidants and exercise performance: with a focus on vitamin E and C supplementation

Based on the structure of Tepotinib, we introduced chiral restriction conformation and hydrogen isotope deuterium to improve its metabolic stability, and synthesized a new structure of small molecule inhibitor 1D228

Szczepanowski P, Noszka M, ya-Uklejewicz D, Pikua F, Nowaczyk-Cieszewska M, et al

To achieve GSH depletion in liver, we engineered an adeno-associated virus (AAV) vector encoding Chac1 fused to a Myc tag, driven by the thyroxine-binding globulin (TBG) promoter to achieve liver-specific overexpression of Chac1 (Figure 1B)
