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More importantly for the tachyphylaxis question, a single snapshot emptying measured once, early in treatment cannot reveal whether the effect is durable

[DOI] [PMC free article] [PubMed] [Google Scholar] Kudelka M

Glutathione synthetase deficiency is an autosomal recessive disorder that was first diagnosed in 1970 in a teenager with a slowly progressive neurologic disorder and markedly elevated excretion of 5-oxoproline in the urine, as well as a history of unexplained jaundice at birth and a history of chronic metabolic acidosis

Identified by CAS number 386264-39-7, this peptide meets traceability and documentation standards required by European research institutions