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These two microarray datasets were detected by the same platform (HG-U133A) Affymetrix Human Genome U133A Array

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During AD, an uncoupling between the insulin receptor (IR) and the insulin receptor substrate 1 (IRS1) occurs as a consequence of the downregulation of IR expression and/or the inactivation of IRS proteins leading to the inability of insulin to promote its normal cellular downstream outcomes

In treating solid tumors, developing more tumor-targeting ASNase is one aspect, and the SLC1A3 inhibitor mentioned earlier also provides an idea to solve this problem